Product ID:FOSCAVIR/FOSCARNET SODIUM INJECTION
MSDS Date:10/05/1991
FSC:6505
NIIN:01-355-7374
MSDS Number: BZGCH

ASTRA PHARMACEUTICAL PRODUCTS INC

50 OTIS ST
WESTBOROUGH, MA 01581-3323
US

Emergency Phone: 800-225-6333/508-366-1100

Info Phone: 508-366-1100/800-225-6333

Cage: 04473

ASTRA PHARMACEUTICAL PRODUCTS INC

WESTBOROUGH, MA 01581-3323 US

Telephone: 508-366-1100/800-225-6333

Cage: 04473

FOSCARNET SODIUM (DIHYDROXYPHOSPHINECARBOXYLIC ACID OXIDE

CAS: 63585-09-1

RTECS: SY8200000

Fraction By Weight: 2.4%

HYDROCHLORIC ACID, HYDROGEN CHLORIDE, MURIATIC ACID

CAS: 7647-01-0

RTECS: MW4025000

Fraction By Weight: <1%

OSHA PEL 5 PPM

ACGIH TLV: C 11 MG/CUM

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

LD50 LC50 Mixture:ORAL LD50(RATS): >2000 MG/KG
Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:FOSCARNET SODIUM SOLUTION HAS A LOW
ACUTE TOXICITY. IT HAS BEEN FOUND TO BIND TO BONE MATRIX. CONTACT
W/SKIN & EYES MAY CAUSE SLIGHT IRRITATION. FOSCARNET SODIUM HAS
BEEN ASSOCIATED OF KIDNEY IMPAIRME NT, THROMBOPHLEBITIS & DECREASES
IN HEMOGLOBIN LEVELS IN CLINICAL PATIENTS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:REDNESS, TEARING, IRRITATION

First Aid:FLUSH EYES & SKIN W/COPIOUS AMOUNTS OF CLEAR WATER FOR 15
MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES.

Flash Point:NON-FLAMMABLE
Extinguishing Media:WATER, DRY CHEMICAL, CO2/FOAM AS APPROPRIATE FOR
ADJACENT MATERIALS
Fire Fighting Procedures:NONE
Unusual Fire/Explosion Hazard:AT HIGH TEMPS, POWDER CAN EMIT TOXIC
FUMES; THIS HAZARD IS NEGLIGIBLE W/RESPECT TO FOSCARNET SODIUM
SOLUTION.

Spill Release Procedures:ABSORB W/INERT MATERIALS.

Handling and Storage Precautions:AVOID SHIPPING/STORING AT TEMPS
<47F/FOSCARNET SODIUM WILL PRECIPITATE DUE TO REDUCED SOLUBILITY.
KEEP IN ORIGINAL, SEALED CONTAINERS.
Other Precautions:MATERIAL SHOULD BE LABELED AS AN IRRITANT & A TOXIC
CHEMICAL. AVOID INGESTION & PROLONGED CONTACT W/SKIN & EYES.

Respiratory Protection:NONE
Ventilation:LOCAL EXHAUST
Protective Gloves:RECOMMENDED
Eye Protection:SAFETY GLASSES RECOMMENDED
Other Protective Equipment:NONE
Supplemental Safety and Health
FOSCARNET SODIUM IS A RELATIVELY NON-TOXIC VIRASTATIC AGENT THAT'S NOT
METABOLIZED & IS RAPIDLY EXCRETED IN URINE. THIS SUBSTANCE IS
SLIGHTLY ABSORBED THROUGH INTACT SKIN WHEN APPLICED PERCUTANEOUSLY.
ALTHOUGH FOSCARNET SODIUM CAN BIND TO BONE MATRIX, IT HAS BEEN
SHOWN TO AFFECT VITAMIN D METABOLISM.

Boiling Pt:B.P. Text:212F
Melt/Freeze Pt:M.P/F.P Text:32F
Vapor Pres:17
Vapor Density:0.6
Spec Gravity:1
Evaporation Rate & Reference:(WATER=1): 1
Solubility in Water:COMPLETE
Appearance and Odor:CLEAR & COLORLESS LIQUID

Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:NONE
Hazardous Decomposition Products:HIGH TEMPS: TOXIC FUMES

Waste Disposal Methods:INCINERATE/DISPOSE OF IN ACCORDANCE W/LOCAL,
STATE & FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.